Here is a great way to deal with blisters on the go thanks to the U.S. Army Survival Handbook. Always keep blisters intact in order for the blister to protect itself. To avoid having a blister burst or tear under pressure and cause an open sore you can drain it.
First get a sterilized sewing needle and clean thread
Clean the area around the blister and run the needle and thread through the blister
Detach the needle and leave the thread hanging out both sides of the blister
The thread will absorb the liquid inside the blister and keep it from bursting
The thread also keeps the hole in the blister from closing up and allows it to dry
Pad around the area to relieve pressure and continue to keep it clean
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